化工社化工社 化学情報印刷レポート · 研究参考用
N-Hydroxyacetamidine → (3EZ,5S)-1-[(2'-chloro 1,1'-biphenyl-4-yl)carbonyl]-5-(3-methyl-1,2,4-oxadiazol-5-yl)-3-pyrrolidinone O-methyloxime
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Hydroxyacetamidine | HCID 30926 | — |
| 反応物 | F 1893 | HCID 160722 | — |
| 反応物 | 2'-Methyl-biphenyl-4-carboxylic acid | HCID 2759815 | — |
| 反応物 | (2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid | HCID 58714586 | — |
| 生成物 | (3EZ,5S)-1-[(2'-chloro 1,1'-biphenyl-4-yl)carbonyl]-5-(3-methyl-1,2,4-oxadiazol-5-yl)-3-pyrrolidinone O-methyloxime | HCID 58714521 | 31% |
反応手順
Following the general methods as outlined in Example 1 (Method B), starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidine-carboxylic acid (Intermediate 2), N′-hydroxyethanimidamide (Intermediate 7) and 2′-chloro[1,1′-biphenyl]-4-carboxylic acid (Intermediate 10), the title compound was isolated, after flash-chromatography, as a mixture of E-/Z-isomers as an oil in 31% yield (98.5% purity by HPLC).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07115639B2 |
| 出典データセット | uspto-grants-2006_10 |
| ORD ID | ord-5ca02eb674b04e83a1b1ea79c70f3835 |
| 出典メモ | uspto-grants-2006_10 |