1-Acetylpiperidine-4-carboxylic acid → HCID 58714535、化合物
反応式
[C:1]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:6]=[CH:5][C:4]([C:7]([N:9]2[CH2:13][C:12](=[N:14][O:15][CH3:16])[CH2:11][C@H:10]2[C:17](=[N:19][OH:20])[NH2:18])=[O:8])=[CH:3][CH:2]=1.[C:27]([N:30]1[CH2:35][CH2:34][CH:33]([C:36](O)=O)[CH2:32][CH2:31]1)(=[O:29])[CH3:28]>>[CH3:16][O:15][N:14]=[C:12]1[CH2:11][C@@H:10]([C:17]2[N:18]=[C:36]([CH:33]3[CH2:34][CH2:35][N:30]([C:27](=[O:29])[CH3:28])[CH2:31][CH2:32]3)[O:20][N:19]=2)[N:9]([C:7]([C:4]2[CH:3]=[CH:2][C:1]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[CH:6][CH:5]=2)=[O:8])[CH2:13]1参加物
3
実験手順
Following the general method as outlined in Example 15, starting from (2S,4EZ)-1-([1,1′-biphenyl]-4-ylcarbonyl)-N′-hydroxy-4-(methoxyimino)-2-pyrrolidinecarboximidamide (Intermediate 8) and 1-acetyl-4-piperidinecarboxylic acid, the title compound was obtained in 87% purity by HPLC. MS(ESI+): m/z=488.4.
出典と根拠
- ORDレコード
- ord-097f507eb3e54c43b8b43085edd72314
- 出典データセット
- uspto-grants-2006_10