化工社化工社 化学情報印刷レポート · 研究参考用
HOAt → n-{(1r)-1-[(4-Chlorophenyl)methyl]-2-oxo-2-[4-(2-pyridylmethyl)piperazinyl]ethyl}(tert-butoxy) carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | HOAt | HCID 181649 | — |
| 反応物 | 1-[(Pyridin-2-yl)methyl]piperazine | HCID 808714 | — |
| 反応物 | N-Boc-4-chloro-D-phenylalanine | HCID 7018791 | — |
| 反応物 | N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide methyliodide | HCID 10236463 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | n-{(1r)-1-[(4-Chlorophenyl)methyl]-2-oxo-2-[4-(2-pyridylmethyl)piperazinyl]ethyl}(tert-butoxy) carboxamide | HCID 69073501 | — |
反応手順
N-{(1R)-1-[(4-Chlorophenyl)methyl]-2-oxo-2-[4-(2-pyridylmethyl)piperazinyl]ethyl}(tert-butoxy) carboxamide was prepared according to the procedure for Preparation XIX using (2-pyridylmethyl)piperazine (650 mg. 3.7 mmol) (Array), Boc-p-Cl-D-Phe-OH (1.1 g, 3.7 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide methiodide (2.2 g, 7.2 mmol), HOAT (560 mg, 4.10 mmol) and DMF (15 mL) (730 mg). MS (ESI, pos. ion) m/z: 459 (M+H), (ESI, neg. ion) m/z: 457 (M−H). Calc'd for C24H31ClN4O3: 458.98.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07115607B2 |
| 出典データセット | uspto-grants-2006_10 |
| ORD ID | ord-15f19197aa654a2691e0dd13c2f4569b |
| 出典メモ | uspto-grants-2006_10 |