Hydrogen chloride-ethyl acetate → HCID 21939817、化合物
反応式
C(OCC)(=O)C.Cl.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([NH:23][C:24]3[CH:44]=[CH:43][C:27]([C:28]([CH:30]4[CH2:35][CH2:34][CH2:33][N:32](C(OC(C)(C)C)=O)[CH2:31]4)=[O:29])=[CH:26][CH:25]=3)=[O:22])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1>>[ClH:8].[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:16]=[CH:17][C:18]([C:21]([NH:23][C:24]3[CH:44]=[CH:43][C:27]([C:28]([CH:30]4[CH2:35][CH2:34][CH2:33][NH:32][CH2:31]4)=[O:29])=[CH:26][CH:25]=3)=[O:22])=[CH:19][CH:20]=2)=[CH:13][CH:14]=1参加物
3
実験手順
4N Hydrogen chloride-ethyl acetate (1 ml) was added to tert-butyl 3-[4-[[(4′-chloro[1,1′-biphenyl]-4-yl)carbonyl]amino]benzoyl]-1-piperidinecarboxylate (100 mg, 0.193 mmol) obtained in 1). One hour later, the solvent was distilled out under reduced pressure. Diisopropyl ether was added to the residue, to give the titled compound (73.3 mg) as a colorless powder.
後処理
- customobtained in 1)
- distillationOne hour later, the solvent was distilled out under reduced pressure
- additionDiisopropyl ether was added to the residue