Hydrochloric Acid → 4-Fluoro-3-methoxyaniline hydrochloride

HRID 1243219ノート

反応式

HRID 1243219 の反応式
C(OC([NH:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[C:11]([O:16][CH3:17])[CH:10]=1)=O)(C)(C)C.[ClH:18]>O1CCOCC1>[ClH:18].[F:15][C:12]1[CH:13]=[CH:14][C:9]([NH2:8])=[CH:10][C:11]=1[O:16][CH3:17]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 21062601(Tert-butoxy)-n-(4-fluoro-3-methoxyphenyl)carboxamide

生成物 1

HCID 219392834-Fluoro-3-methoxyaniline hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

(tert-Butoxy)-N-(4-fluoro-3-methoxyphenyl)carboxamide (0.98 g, 4.06 mmol) (from Example 34c supra) was treated with 4 N hydrochloric acid in dioxane (20 mL) (Aldrich) overnight at room temperature. The resulting precipitate was collected by filtration and washed with dry ether to give 4-fluoro-3-methoxyphenylamine hydrochloric acid salt as a white, crystalline, solid. (Yield 512 mg, 71%).

後処理

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with dry ether

出典と根拠

ORDレコード
ord-8c860e4d6b594c88a30618a5e7f3bf63
出典データセット
uspto-grants-2006_10
特許番号
US07115740B2

反応ノート

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