1-Bromooctane → 1-Bromo-4-(4-octoxyphenyl)benzene

HRID 1243250

反応式

HRID 1243250 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Br[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 81401-BromooctaneHCID 11430Potassium CarbonateHCID 950934-Bromo-4'-hydroxybiphenyl

生成物 1

HCID 28017871-Bromo-4-(4-octoxyphenyl)benzene収率 66%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

A mixture of 4-bromo-4′-hydroxybiphenyl (50.00 g, 0.2008 mol), 1-bromooctane (50.38 g, 0.2610 mol), potassium carbonate (47.11 g, 0.3414 mol) and butanone (500 cm3) was heated under reflux overnight. The cooled mixture was filtered and the solvent removed on a rotary evaporator. The crude solid was recrystallised from ethanol to yield a white crystalline solid (47.30 g, 66%, m.pt. 120° C.).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux overnight
  3. filtrationThe cooled mixture was filtered
  4. customthe solvent removed on a rotary evaporator
  5. customThe crude solid was recrystallised from ethanol

出典と根拠

ORDレコード
ord-25cd1da99c1943748b340fcf01f82f0e
出典データセット
uspto-grants-2006_10
特許番号
US07118787B2

関連ノート

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