2-Bromopyridine → 1-(PYRIDIN-2-YL)-1,4-DIAZEPANE

HRID 1243328ノート

反応式

HRID 1243328 の反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:8]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1>O>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[N:8]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1

参加物

4

反応物 2

HCID 79732-BromopyridineHCID 68163Hexahydro-1,4-diazepine

生成物 1

HCID 27724021-(PYRIDIN-2-YL)-1,4-DIAZEPANE

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

A mixture of 2-bromopyridine and 12 g of homopiperazine is heated at 100° C. for 6 hours. 50 ml of water are added to the reaction mixture and the resulting mixture is extracted with EtOAc, the organic phase is washed with saturated NaCl solution and dried over Na2SO4, and the solvent is evaporated off under vacuum. 1.28 g of the expected product are obtained.

後処理

  1. extractionthe resulting mixture is extracted with EtOAc
  2. washthe organic phase is washed with saturated NaCl solution
  3. dry with materialdried over Na2SO4
  4. customthe solvent is evaporated off under vacuum

出典と根拠

ORDレコード
ord-6e8e0d76255349c9aaacd4e64da19443
出典データセット
uspto-grants-2006_10
特許番号
US07119086B2

反応ノート

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