Diethylamine → HCID 85961308、化合物

HRID 1244256

反応式

HRID 1244256 の反応式
[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].[CH2:6]([O:8][C:9]([C:11]1[N:12]=[N:13][C:14]([Cl:18])=[CH:15][C:16]=1Cl)=[O:10])[CH3:7]>C(OCC)(=O)C>[CH2:6]([O:8][C:9]([C:11]1[N:12]=[N:13][C:14]([Cl:18])=[CH:15][C:16]=1[N:3]([CH2:4][CH3:5])[CH2:1][CH3:2])=[O:10])[CH3:7]

参加物

4

反応物 2

HCID 8021DiethylamineHCID 53428795Ethyl 4,6-dichloropyridazine-3-carboxylate

生成物 1

HCID 85961308HCID 85961308、化合物収率 98.1%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Diethylamine (86 mg, 1.3 equivalents, 1.2 mmol) is added to a solution of 4,6-dichloro-pyridazine-3-carboxylic acid ethyl ester (0.2 g, 0.91 mmol) in ethyl acetate (10 mL) at room temperature. After overnight stirring, the reaction is quenched with water (6 mL). The organic layer is separated and the aqueous layer extracted (2×15 mL) with ethyl acetate. The combined organic layers are dried and solvent removed to give 230 mg of 6-chloro-4-diethylamino-pyridazine-3-carboxylic acid ethyl ester as a yellowish oil.

後処理

  1. customthe reaction is quenched with water (6 mL)
  2. customThe organic layer is separated
  3. extractionthe aqueous layer extracted (2×15 mL) with ethyl acetate
  4. customThe combined organic layers are dried
  5. customsolvent removed

出典と根拠

ORDレコード
ord-9e8b97256656485b83fc086a99a545bc
出典データセット
uspto-grants-2006_10
特許番号
US07122546B2

関連ノート

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