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4-Aminobenzamide → 4-((4-(4-Chlorophenyl)pyrimidin-2-yl)amino)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminobenzamide | HCID 76079 | — |
| 反応物 | 4-(4-Chlorophenyl)-2-(methylsulfonyl)pyrimidine | HCID 21905993 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 4-((4-(4-Chlorophenyl)pyrimidin-2-yl)amino)benzamide | HCID 10041964 | — |
反応手順
To a solution of 4-(4-chlorophenyl)-2-(methylsulfonyl)pyrimidine (0.10 g, 0.37 mmol) and 4-aminobenzamide in 2-propanol (3 ml) was heated to 120° C. in a sealed vessel for 14 hours. The crude material was concentrated and purified by preparative HPLC to provide the title compound as a beige solid: LC/MS Retention Time; 6.30 min (Method A), M+1; 325.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07122544B2 |
| 出典データセット | uspto-grants-2006_10 |
| ORD ID | ord-498f10ffeb2c4d1d983dfba8bd674c4f |
| 出典メモ | uspto-grants-2006_10 |