Potassium Hydroxide → 2-(1H-imidazol-2-yl)-4-methoxy-7-morpholin-4-yl-benzothiazole

HRID 1244310ノート

反応式

HRID 1244310 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[CH:5][C:4]=1[NH:15][C:16]([C:18]1[NH:19][CH:20]=[CH:21][N:22]=1)=[S:17].[OH-].[K+]>O.[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.[K+].[K+].[K+].[K+].[Fe+6]>[NH:22]1[CH:21]=[CH:20][N:19]=[C:18]1[C:16]1[S:17][C:5]2[C:6]([N:9]3[CH2:10][CH2:11][O:12][CH2:13][CH2:14]3)=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[C:4]=2[N:15]=1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 865949991H-imidazole-2-carbothioic acid (2-methoxy-5-morpholin-4-yl-phenyl)-amide

生成物 1

HCID 1354097702-(1H-imidazol-2-yl)-4-methoxy-7-morpholin-4-yl-benzothiazole収率 47%

試薬・触媒・溶媒 2

HCID 11963580Ferrate(4-), hexakis(cyano-C)-, tetrapotassium, (OC-6-11)-触媒HCID 962Water溶媒2 回

実験手順

0.08 g of 1H-Imidazole-2-carbothioic acid (2-methoxy-5-morpholin-4-yl-phenyl)-amide (0.25 mmol) were taken up in water (2.0 ml) and treated with 0.056 g KOH (1.0 mmol) and 0.331 g of potassium hexacyano ferrate (1.0 mmol) at reflux for 1 h. After cooling to ambient temperature water (10 ml) was added and the mixture was filtered. The residue on the filter was dried in vacuo at 40° C. One obtained 0.037 g of 2-(1H-imidazol-2-yl)-4-methoxy-7-morpholin-4-yl-benzothiazole (47%) as a yellow solid; M.p.: 228–230° C.

後処理

  1. temperatureat reflux for 1 h
  2. additionwas added
  3. filtrationthe mixture was filtered
  4. customThe residue on the filter was dried in vacuo at 40° C

出典と根拠

ORDレコード
ord-ef0aa20d8251450395730ac678b1223d
出典データセット
uspto-grants-2006_10
特許番号
US07122545B2

反応ノート

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