Sulfuric Acid → HCID 10336428、化合物

HRID 1244548ノート

反応式

HRID 1244548 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[C:19](=[O:20])[CH2:18][CH:17]([C:21]([OH:23])=[O:22])[CH2:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.Cl[CH2:30]Cl>CO>[CH3:30][O:22][C:21]([CH:17]1[CH2:18][C:19](=[O:20])[N:15]([C:12]2[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:10][CH:11]=2)[CH2:16]1)=[O:23]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 6344DichloromethaneHCID 2968114STK087815

生成物 1

HCID 10336428HCID 10336428、化合物収率 93%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

7.46 g (24 mmol) (RS)-1-(4-benzyloxy-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid is dissolved in a mixture of 40 ml dichloromethane and 7.5 ml methanol. 0.13 ml concentrated sulfuric acid is added and the reaction mixture hold under reflux over night. The solvent is evaporated and the residue triturated with diethyl ether to yield 7.26 g (93%) of a colorless solid (used in the next step without further purification).

後処理

  1. temperaturethe reaction mixture hold under reflux over night
  2. customThe solvent is evaporated
  3. customthe residue triturated with diethyl ether

出典と根拠

ORDレコード
ord-5dcaa54585db449f9338e0b2d36fc772
出典データセット
uspto-grants-2006_10
特許番号
US07122562B2

反応ノート

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