HCID 1268221、化合物 → N-Fmoc-amino-4-ketocyclohexylcarboxylic acid

HRID 1244671ノート

反応式

HRID 1244671 の反応式
[CH:1]1[C:13]2[CH:12]([CH2:14][O:15][C:16]([NH:18][C:19]3([C:29]([OH:31])=[O:30])[CH2:28][CH2:27][C:22]4(OCC[O:23]4)[CH2:21][CH2:20]3)=[O:17])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1>CC(C)=O>[CH:1]1[C:13]2[CH:12]([CH2:14][O:15][C:16]([NH:18][C:19]3([C:29]([OH:31])=[O:30])[CH2:20][CH2:21][C:22](=[O:23])[CH2:27][CH2:28]3)=[O:17])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

参加物

3

反応物 1

HCID 1268221HCID 1268221、化合物

生成物 1

HCID 1268238N-Fmoc-amino-4-ketocyclohexylcarboxylic acid

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

187 mmol (79 g) of 8-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1,4-dioxaspiro[4,5]decane-8-carboxylic acid is taken up in 3.51 of acetone/0.1 M HCl 1:1 and stirred for 4 hours at room temperature. The acetone is drawn off in a rotary evaporator, and the precipitated product is filtered off, rewashed with water and dried. Yield: 68.7 g of 2.

後処理

  1. customThe acetone is drawn off in a rotary evaporator
  2. filtrationthe precipitated product is filtered off
  3. customdried

出典と根拠

ORDレコード
ord-aaac8efa1a764629999d2b22682c26f6
出典データセット
uspto-grants-2006_10
特許番号
US07122570B2

反応ノート

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