(+/-)-(3,3-Dimethyl-1-nitromethyl-cyclopentyl)-acetic Acid Ethyl Ester → HCID 21923172、化合物
反応式
C([O:3][C:4](=O)[CH2:5][C:6]1([CH2:13][N+:14]([O-])=O)[CH2:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7]1)C>[Ni].CO>[CH3:11][C:8]1([CH3:12])[CH2:9][CH2:10][C:6]2([CH2:13][NH:14][C:4](=[O:3])[CH2:5]2)[CH2:7]1参加物
4
実験手順
The ester 3 (380 mg, 1.6 mmol) and Raney Nickel (1 g) were suspended in methanol (75 mL) and shaken under a hydrogen atmosphere for 24 hours. The catalyst was removed by filtration, the filtrate concentrated to give the lactam 4 (246 mg, 94%) as a white solid.
後処理
- customThe catalyst was removed by filtration
- concentrationthe filtrate concentrated
出典と根拠
- ORDレコード
- ord-a4328a571a1649658258e77b5f7d3282
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07122678B2
反応ノート
読み込み中…