1-Butanol → 2-chloro-N-(phenylmethyl)-9-(tetrahydro-3-thienyl)-9H-purin-6-amine

HRID 1244892ノート

反応式

HRID 1244892 の反応式
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][S:13][CH2:12]2)=[C:4](Cl)[N:3]=1.C(O)CCC.[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>C(O)(C)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][S:13][CH2:12]2)=[C:4]([NH:29][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:3]=1

参加物

5

反応物 3

HCID 2631-ButanolHCID 7504BenzylamineHCID 219229912,6-dichloro-9-(tetrahydro-3-thienyl)-9H-purine

生成物 1

HCID 219229482-chloro-N-(phenylmethyl)-9-(tetrahydro-3-thienyl)-9H-purin-6-amine

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

反応条件

温度
97.5 °C

実験手順

120 mg of the product obtained in Stage 1 above, 2 ml of butanol and 0,105 ml of benzylamine are mixed together and the reaction medium is heated to a temperature of approximately 95 to 100° C. for 10 hours. It is then left to return to ambient temperature and diluted with 5 ml of isopropanol, followed by separating, washing with 5 ml of isopropanol and drying under vacuum at approximately 30° C. In this way 132 mg of expected product is obtained in the form of white crystals.

後処理

  1. waitIt is then left
  2. customto return to ambient temperature
  3. customby separating
  4. washwashing with 5 ml of isopropanol
  5. customdrying under vacuum at approximately 30° C

出典と根拠

ORDレコード
ord-6b7b1c61bad14193abe471c172d54064
出典データセット
uspto-grants-2006_10
特許番号
US07122669B1

反応ノート

読み込み中…