(4-Methoxyphenyl)boronic acid → HCID 58717609、化合物

反応式

Br[C:2]1[CH:3]=[CH:4][C:5](OCCCCCCC)=[C:6]([CH:38]=1)[C:7]([NH:9][C@@H:10]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2OC2C=CC(C(F)(F)F)=CC=2)=[CH:17][CH:16]=1)[C:11]([OH:13])=[O:12])=[O:8].[CH3:47][O:48][C:49]1[CH:54]=[CH:53][C:52](B(O)O)=[CH:51][CH:50]=1>>[C:18]1([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:17]=[CH:16][C:15]([CH2:14][C@H:10]([NH:9][C:7]([C:6]2[CH:38]=[C:2]([C:52]3[CH:53]=[CH:54][C:49]([O:48][CH3:47])=[CH:50][CH:51]=3)[CH:3]=[CH:4][CH:5]=2)=[O:8])[C:11]([OH:13])=[O:12])=[CH:20][CH:19]=1

参加物

反応物 2

HCID 201262(4-Methoxyphenyl)boronic acid

HCID 58717681HCID 58717681、化合物

生成物 1

HCID 58717609HCID 58717609、化合物収率 81.9%

実験手順

3-Biphenyl-4-yl-(2S)-[(3-bromo-benzoyl-amino)-propionic acid (100 mg, 0.23 mmol) was reacted with 4-methoxy-phenyl boronic acid (0.106 mg, 0.69 mmol) by following general procedure D yielding the title compound (85 mg, 80%) as a white solid.

出典と根拠

ORDレコード: ord-1a828a81ca9e4060a4da644a2aa46d77
出典データセット: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07122580B2

反応ノート

読み込み中…