化工社化工社 化学情報印刷レポート · 研究参考用
N-bromobutanimide → Ethyl 5-bromo-4-methylthiazole-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | Ethyl 4-methyl-1,3-thiazole-2-carboxylate | HCID 567306 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Ethyl 5-bromo-4-methylthiazole-2-carboxylate | HCID 59338079 | — |
反応手順
To a solution of 4-methyl-thiazole-2-carboxylic acid ethyl ester (171 mg, 1.0 mmol) in acetonitrile (5 ml) is added NBS (180 mg, 1.0 mmol). The reaction mixture is stirred at rt for 2 hr followed by the addition of a second portion of NBS (180 mg, 1.0 mmol). After stirring at rt for 3 hr, the solvent is removed. The resulting residue is purified by PTLC to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728009B1 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-84ab61881c3f4d459047f990649b7d88 |
| 出典メモ | uspto-grants-2010_06 |