N-bromobutanimide → Ethyl 5-bromo-4-methylthiazole-2-carboxylate

HRID 12451

反応式

HRID 12451 の反応式
[CH2:1]([O:3][C:4]([C:6]1[S:7][CH:8]=[C:9]([CH3:11])[N:10]=1)=[O:5])[CH3:2].C1C(=O)N([Br:19])C(=O)C1>C(#N)C>[CH2:1]([O:3][C:4]([C:6]1[S:7][C:8]([Br:19])=[C:9]([CH3:11])[N:10]=1)=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 67184N-bromobutanimide2 回HCID 567306Ethyl 4-methyl-1,3-thiazole-2-carboxylate

生成物 1

HCID 59338079Ethyl 5-bromo-4-methylthiazole-2-carboxylate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of 4-methyl-thiazole-2-carboxylic acid ethyl ester (171 mg, 1.0 mmol) in acetonitrile (5 ml) is added NBS (180 mg, 1.0 mmol). The reaction mixture is stirred at rt for 2 hr followed by the addition of a second portion of NBS (180 mg, 1.0 mmol). After stirring at rt for 3 hr, the solvent is removed. The resulting residue is purified by PTLC to give the title compound.

後処理

  1. stirringAfter stirring at rt for 3 hr
  2. customthe solvent is removed
  3. customThe resulting residue is purified by PTLC

出典と根拠

ORDレコード
ord-84ab61881c3f4d459047f990649b7d88
出典データセット
uspto-grants-2010_06
特許番号
US07728009B1

関連ノート

読み込み中…