関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 1-Naphthaleneboronic acid | HCID 254532 | — |
| 反応物 | Ethyl 5-bromo-4-methylthiazole-2-carboxylate | HCID 59338079 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 4-Methyl-5-naphthalen-1-yl-thiazole-2-carboxylic acid ethyl ester | HCID 59338449 | — |
反応手順
To a solution of 5-bromo-4-methyl-thiazole-2-carboxylic acid ethyl ester (60 mg, 0.24 mmol) in 1,4-dioxane (2 ml) is added 1-naphthaleneboronic acid (50 mg, 0.29 mmol), cesium carbonate (187 mg, 0.58 mmol) and Pd(PPh3)4 (28 mg, 0.024 mmol). The reaction mixture is stirred in a sealed tube at 110° C. overnight. After cooling to rt, the mixture is purified by PTLC to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07728009B1 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-9f1c3eae5e914686a5941e976dd60d69 |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
