Triphenylphosphine → HCID 69664641、化合物

HRID 1245333ノート

反応式

HRID 1245333 の反応式
[OH:1][C:2]1[CH:14]=[CH:13][C:5]2[C:6]([C:9]([F:12])([F:11])[F:10])=[N:7][O:8][C:4]=2[C:3]=1[CH2:15][CH2:16][CH3:17].[Si:18]([O:25][CH2:26][CH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][CH:28]1O)([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CC(OC(/N=N/C(OC(C)C)=O)=O)C>>[Si:18]([O:25][CH2:26][C@H:27]1[CH2:28][CH2:29][CH2:30][CH2:31][C@H:32]1[O:1][C:2]1[CH:14]=[CH:13][C:5]2[C:6]([C:9]([F:12])([F:11])[F:10])=[N:7][O:8][C:4]=2[C:3]=1[CH2:15][CH2:16][CH3:17])([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19]

参加物

5

反応物 4

HCID 11776TriphenylphosphineHCID 5363146Diisopropyl azodicarboxylateHCID 452576462-({[tert-Butyl(dimethyl)silyl]oxy}methyl)cyclohexan-1-olHCID 1358008127-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-ol

生成物 1

HCID 69664641HCID 69664641、化合物

実験手順

A mixture of 6-hydroxy-7-propyl-3-(trifluoromethyl)-1,2-benzisoxazole (730 mg, 2.98 mmol), 2-({tert-butyl(dimethyl)silyloxy}methyl)-cyclohexanol (800 mg, 3.28 mmol) from this Example step 1, and triphenylphosphine (1.02 g, 3.874 mmol) was dissolved in dry benzenes (16 mL). Diisopropylazodicarboxylate (0.78 mL, 3.874 mmol) was added dropwise. The reaction mixture was stirred at room temperature overnight. The solvent was evaporated in vacuo and the residue purified by chromatography on silica gel using acetone and hexane (1:99) to give the title compound.

後処理

  1. customThe solvent was evaporated in vacuo
  2. customthe residue purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-1c13846d93fd460ab599c5db2db297b3
出典データセット
uspto-grants-2006_10
特許番号
US07125865B2

反応ノート

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