Boron tribromide → 2-(2,4-Dichlorophenyl)benzoxazol-5-ol

HRID 1245365

反応式

HRID 1245365 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[O:10][C:11]2[CH:17]=[CH:16][C:15]([O:18]C)=[CH:14][C:12]=2[N:13]=1.B(Br)(Br)Br>ClCCl>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[O:10][C:11]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][C:12]=2[N:13]=1

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 219116842-(2,4-Dichlorophenyl)-5-methoxybenzoxazole

生成物 1

HCID 219117282-(2,4-Dichlorophenyl)benzoxazol-5-ol

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

2-(2,4-dichlorophenyl)-5-methoxybenzoxazole (0.5 g, 1.7 mmol) was dissolved in 25 mL dichloromethane. To the solution was added boron tribromide (8 mmol) and the mixture was allowed to stir at room temperature for 48 hours. The mixture was then diluted with 25 mL dichloromethane and washed sequentially with saturated sodium bicarbonate (2×25 mL), followed by brine. The organic layer was separated, dried over MgSO4 and filtered. The solvent was removed under reduced pressure, to provide 2-(2,4-dichlorophenyl)benzoxazol-5-ol, which was purified using flash chromatography.

後処理

  1. washwashed sequentially with saturated sodium bicarbonate (2×25 mL)
  2. customThe organic layer was separated
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-df525709af4e439e997e9f343e88b270
出典データセット
uspto-grants-2006_10
特許番号
US07125876B2

関連ノート

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