Methyl butadienecarboxylate → HCID 69640073、化合物

HRID 1245397ノート

反応式

HRID 1245397 の反応式
[CH3:1][O:2][C:3](=[O:8])[CH:4]=[CH:5][CH:6]=[CH2:7].[CH3:9][C:10]1[CH:19]=[C:18]([CH2:20][O:21][C:22]2[CH:30]=[CH:29][C:25]([CH:26]=[N:27][OH:28])=[CH:24][CH:23]=2)[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1>>[CH3:1][O:2][C:3](=[O:8])[CH:4]=[CH:5][CH:6]1[O:28][N:27]=[C:26]([C:25]2[CH:24]=[CH:23][C:22]([O:21][CH2:20][C:18]3[C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[N:11]=[C:10]([CH3:9])[CH:19]=3)=[CH:30][CH:29]=2)[CH2:7]1

参加物

3

反応物 2

HCID 73688Methyl butadienecarboxylateHCID 738530794-(2-Methyl-quinolin-4-ylmethoxy)-benzaldehyde oxime

生成物 1

HCID 69640073HCID 69640073、化合物収率 73%

実験手順

Following a procedure analogous to that used in Example step 1c, but using penta-2,4-dienoic acid methyl ester and 4-(2-methyl-quinolin-4-ylmethoxy)-benzaldehyde oxime from step 1b, the crude reaction was partitioned between ethyl acetate and water, and the organic layer was washed with brine, dried over magnesium sulfate, and concentrated to give 3-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-4,5-dihydro-isoxazol-5-yl}-acrylic acid methyl ester (2.57 g, 73%) as a white powder. MS found: (M+H)+=403.

後処理

  1. customthe crude reaction
  2. customwas partitioned between ethyl acetate and water
  3. washthe organic layer was washed with brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-d0507e7b1ec34244903438c05c721aa7
出典データセット
uspto-grants-2006_10
特許番号
US07125870B2

反応ノート

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