Sodium Cyanide → 5-Chloro-4-[(4-chlorophenyl)amino]-6-morpholin-4-ylpyrimidine-2-carbonitrile

HRID 1245420ノート

反応式

HRID 1245420 の反応式
[C-:1]#[N:2].[Na+].[Cl:4][C:5]1[C:6]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)=[N:7][C:8](F)=[N:9][C:10]=1[N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>CS(C)=O>[Cl:4][C:5]1[C:6]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)=[N:7][C:8]([C:1]#[N:2])=[N:9][C:10]=1[N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1

参加物

4

反応物 2

HCID 8929Sodium CyanideHCID 219124595-chloro-N-(4-chlorophenyl)-2-fluoro-6-morpholin-4-ylpyrimidin-4-amine

生成物 1

HCID 99751475-Chloro-4-[(4-chlorophenyl)amino]-6-morpholin-4-ylpyrimidine-2-carbonitrile

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

Sodium cyanide (0.057 g) was added to a solution of the product from step (ii) (0.2 g) in dimethylsulphoxide (5 ml) and the mixture stirred at room temperature. After 18 h, the mixture was partitioned between ethyl acetate and water, the organics separated, washed with water, dried (MgSO4) and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 5% ethyl acetate in toluene. Yield 0.09 g

後処理

  1. customthe mixture was partitioned between ethyl acetate and water
  2. washthe organics separated, washed with water
  3. dry with materialdried (MgSO4)
  4. customevaporated under reduced pressure
  5. customThe residue was purified by chromatography on silica eluting with 5% ethyl acetate in toluene

出典と根拠

ORDレコード
ord-9b1c15c5dfed432f9e2848d9e640daaa
出典データセット
uspto-grants-2006_10
特許番号
US07125881B2

反応ノート

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