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Water → tert-Butyl (5,6-dimethyl-1H-benzimidazol-2-yl)methylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | tert-butyl N-(cyanomethyl)carbamate | HCID 545844 | — |
| 反応物 | 4,5-Diamino-ortho-xylene bishydrochloride | HCID 12210957 | — |
| 反応物 | HCID 178418582 | HCID 178418582 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | tert-Butyl (5,6-dimethyl-1H-benzimidazol-2-yl)methylcarbamate | HCID 86760280 | — |
反応手順
1.3 g of a 30% NaOCH3 solution were added to tert-butyl cyanomethylcarbamate (0.4 g; 25.6 mmol) in 10 ml of CH3OH, and the mixture was stirred at room temperature for 1 h. After addition of 5.15 g of 4,5-diamino-ortho-xylene bishydrochloride, the reaction mixture was stirred overnight and then added to 100 ml of H2O, and the solid obtained by filtration was dried at 30° C. in vacuo. 0.5 g; ESI-MS [M+H+]=276
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07125883B1 |
| 出典データセット | uspto-grants-2006_10 |
| ORD ID | ord-d90121ed27e544c4a8893b6b9fd7a1be |
| 出典メモ | uspto-grants-2006_10 |