2,4-Dichloro-6-methylbenzenesulfonyl chloride → Ethyl 3-(2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-3-methylbutanoate

HRID 1245642ノート

反応式

HRID 1245642 の反応式
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([CH3:15])([CH3:14])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[N:6]=1.[Cl:16][C:17]1[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([CH3:24])[C:18]=1[S:25](Cl)(=[O:27])=[O:26]>>[Cl:16][C:17]1[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([CH3:24])[C:18]=1[S:25]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([CH3:14])([CH3:15])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[N:6]=1)(=[O:27])=[O:26]

参加物

3

反応物 2

HCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chlorideHCID 21914681HCID 21914681、化合物

生成物 1

HCID 10225906Ethyl 3-(2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-3-methylbutanoate

実験手順

The title compound was prepared from ethyl 3-(2-amino-1,3-thiazol-4-yl)-3-methylbutanoate (METHOD I) and 2,4-dichloro-6-methylbenzenesulfonyl chloride as described in the synthetic method to give a white solid (55.0 mg) with purity >90%. MS (pos) m/z 451.2, 453.2.

出典と根拠

ORDレコード
ord-88f5b3c88e4b45a3b4c8e2de5a494adf
出典データセット
uspto-grants-2006_10
特許番号
US07125900B2

反応ノート

読み込み中…