Dimethylformamide → 2-(2-bromophenoxy)ethanol
反応式
C(=O)([O-])[O-].[K+].[K+].[Br:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[OH:14].CN(C)C=O.Br[CH2:21][CH2:22][OH:23]>O>[Br:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][CH2:21][CH2:22][OH:23]参加物
6
反応条件
- 温度
- 50 °C
実験手順
Potassium carbonate (23.8 g) and 2-bromophenol (14.9 g) were mixed with dimethylformamide (150 ml). 2-Bromoethanol (12.9 g) was added and the mixture heated to 50° C. for 18 h. The mixture was cooled and added to water (1500 ml). The product was extracted into diethyl ether (×3) and washed twice with dilute sodium hydroxide solution. Evaporation gave 2-(2-bromophenoxy)ethanol (17.4 g).
後処理
- temperatureThe mixture was cooled
- extractionThe product was extracted into diethyl ether (×3)
- washwashed twice with dilute sodium hydroxide solution
- customEvaporation
出典と根拠
- ORDレコード
- ord-617afdc610814f1a89167903bbd13fcc
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07125896B2
反応ノート
読み込み中…