Morpholine → 4-(4-Bromo-2-fluorobenzyl)morpholine

HRID 1245836ノート

反応式

HRID 1245836 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[C:4]([F:10])[CH:3]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>CN(C)C=O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[C:4]([F:10])[CH:3]=1

参加物

4

反応物 2

HCID 8083MorpholineHCID 27336604-Bromo-2-fluorobenzyl bromide

生成物 1

HCID 219145034-(4-Bromo-2-fluorobenzyl)morpholine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4-Bromo-2-fluorobenzyl bromide (3.0 g) and morpholine (2.15 ml) were stirred in dimethylformamide (30 ml) at ambient temperature for 18 h. The mixture was partitioned between diethyl ether (80 ml) and water (80 ml). The aqueous phase was extracted further with diethyl ether (80 ml) and the combined organic phases were dried (magnesium sulfate) and concentrated in vacuo. The residue was purified by column chromatography, eluting with a gradient of 0–30% ethyl acetate/iso-hexane to give the product as a colourless oil (2.92 g).

後処理

  1. customThe mixture was partitioned between diethyl ether (80 ml) and water (80 ml)
  2. extractionThe aqueous phase was extracted further with diethyl ether (80 ml)
  3. dry with materialthe combined organic phases were dried (magnesium sulfate)
  4. concentrationconcentrated in vacuo
  5. customThe residue was purified by column chromatography
  6. washeluting with a gradient of 0–30% ethyl acetate/iso-hexane

出典と根拠

ORDレコード
ord-c8e00cdb47be467991686a50f45fdff7
出典データセット
uspto-grants-2006_10
特許番号
US07125896B2

反応ノート

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