Triethylamine → 1-Isopropylpyrrolidin-3-yl methanesulphonate

HRID 1245864ノート

反応式

HRID 1245864 の反応式
[CH:1]([N:4]1[CH2:8][CH2:7][CH:6]([OH:9])[CH2:5]1)([CH3:3])[CH3:2].C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>C1(C)C=CC=CC=1>[CH3:17][S:18]([O:9][CH:6]1[CH2:7][CH2:8][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5]1)(=[O:20])=[O:19]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 113095221-Isopropyl-3-pyrrolidinol

生成物 1

HCID 219143101-Isopropylpyrrolidin-3-yl methanesulphonate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 1-isopropylpyrrolidin-3-ol (2.0 ml) and triethylamine (2.5 ml) in toluene (25 ml) was cooled to 0° C. and methanesulphonyl chloride (1.4 ml) was added dropwise with stirring. The mixture was allowed to warm to ambient temperature and is stirred for a further 2 h. The reaction was filtered and the filtrate evaporated to an oil which was used immediately.

後処理

  1. stirringis stirred for a further 2 h
  2. filtrationThe reaction was filtered
  3. customthe filtrate evaporated to an oil which

出典と根拠

ORDレコード
ord-ed3c7d0be0ba42f19ab36df53cbbbbe0
出典データセット
uspto-grants-2006_10
特許番号
US07125896B2

反応ノート

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