Potassium Iodide → HCID 21914295、化合物
反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:9][CH2:10]Cl.Cl.[F:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:9][CH2:10][N:17]1[CH2:18][CH2:19][CH:14]([F:13])[CH2:15][CH2:16]1参加物
6
反応条件
- 温度
- 80 °C
実験手順
A mixture of 1-bromo-2-(2-chloroethoxy)benzene (2.35 g), 4-fluoropiperidine hydrochloride (1.54 g), potassium carbonate (4.06 g) and potassium iodide (0.83 g) in dimethylformamide (20 ml) was heated at 80° C. for 18 h. After evaporation, the residue was partitioned between ethyl acetate and water. The solvent phase was washed (brine), dried and evaporated to give an oil (1.0 g).
後処理
- customAfter evaporation
- customthe residue was partitioned between ethyl acetate and water
- washThe solvent phase was washed (brine)
- customdried
- customevaporated
出典と根拠
- ORDレコード
- ord-24fcf650e6e24c0fb4c7937b5076ece4
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07125896B2
反応ノート
読み込み中…