5-Chlorooxindole → 5-(5-Chloro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

反応式

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH2:12]([O:14][C:15]([C:17]1[NH:18][C:19]([CH:23]=O)=[C:20]([CH3:22])[CH:21]=1)=[O:16])[CH3:13]>>[CH2:12]([O:14][C:15]([C:17]1[NH:18][C:19]([CH:23]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Cl:1])[CH:3]=3)[NH:7][C:6]2=[O:11])=[C:20]([CH3:22])[CH:21]=1)=[O:16])[CH3:13]

参加物

反応物 2

HCID 1528015-Chlorooxindole

HCID 9855648Ethyl 5-formyl-4-methyl-1H-pyrrole-2-carboxylate

生成物 1

HCID 672810735-(5-Chloro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4-methyl-1H-pyrrole-2-carboxylic acid ethyl ester収率 94%

実験手順

5-Chloro-1,3-dihydroindol-2-one (2.22 g, 13.2 mmol) was condensed with 5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid ethyl ester (2.43 g) using method E to give 4.1 g (94%) of the title compound as an orange solid.

出典と根拠

ORDレコード: ord-b0167678838b4dd4b9b44a7dd79c379e
出典データセット: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07125905B2

反応ノート

読み込み中…