Sodium Cyanide → 2-(5-Chloro-2-phenyl-1-benzothiophen-3-yl)acetonitrile

HRID 1246395ノート

反応式

HRID 1246395 の反応式
[C-:1]#[N:2].[Na+].Br[CH2:5][C:6]1[C:10]2[CH:11]=[C:12]([Cl:15])[CH:13]=[CH:14][C:9]=2[S:8][C:7]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CS(C)=O>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]2[S:8][C:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[C:6]([CH2:5][C:1]#[N:2])[C:10]=2[CH:11]=1

参加物

4

反応物 2

HCID 8929Sodium CyanideHCID 219167743-Bromomethyl-5-chloro-2-phenylbenzo[b]thiophene

生成物 1

HCID 219172462-(5-Chloro-2-phenyl-1-benzothiophen-3-yl)acetonitrile

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
60 °C

実験手順

1.2 eq. of NaCN are suspended in 20 ml of dimethyl sulphoxide. The mixture is heated at 60° C. for 30 minutes and then 1 eq. of the compound obtained in Step C is added gradually. The reaction mixture is stirred for 1 hour at 60° C. and is then hydrolysed. Extraction with ethyl acetate is carried out and the organic phase is washed with water, dried over MgSO4 and evaporated under reduced pressure. The residue obtained is purified by chromatography on silica gel.

後処理

  1. extractionExtraction with ethyl acetate
  2. washthe organic phase is washed with water
  3. dry with materialdried over MgSO4
  4. customevaporated under reduced pressure
  5. customThe residue obtained
  6. customis purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-a9f8bfc8d43b4172886b30598cb953f5
出典データセット
uspto-grants-2006_10
特許番号
US07126012B2

反応ノート

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