Potassium Carbonate → N-[4-(Hydroxymethyl)-1,3-thiazol-2-YL]acetamide
反応式
C([O:4][CH2:5][C:6]1[N:7]=[C:8]([NH:11][C:12](=[O:14])[CH3:13])[S:9][CH:10]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:4][CH2:5][C:6]1[N:7]=[C:8]([NH:11][C:12](=[O:14])[CH3:13])[S:9][CH:10]=1参加物
4
実験手順
A mixture of (2-(acetylamino)-1,3-thiazol-4-yl)methyl acetate (46 g) and potassium carbonate (30 g) in methanol (640 ml) was stirred for 3 hours at ambient temperature. The reaction mixture was concentrated in vacuo. The residue was diluted with chloroform, and the insoluble material was filtered off. The resulting solution was purified by flash column chromatography on silica-gel with methanol/chloroform (1/99). The resulted solid was collected by filtration with isopropyl ether to give N-(4-(hydroxymethyl)-1,3-thiazol-2-yl)acetamide (35 g) as white crystals.
後処理
- concentrationThe reaction mixture was concentrated in vacuo
- additionThe residue was diluted with chloroform
- filtrationthe insoluble material was filtered off
- customThe resulting solution was purified by flash column chromatography on silica-gel with methanol/chloroform (1/99)
- filtrationThe resulted solid was collected by filtration with isopropyl ether
出典と根拠
- ORDレコード
- ord-e25449450da046fc98a4239639a3803e
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07125901B2
反応ノート
読み込み中…