Ethyl bromopyruvate → Ethyl 2-aminothiazole-4-carboxylate hydrobromide
反応式
[Br:1][CH2:2][C:3](=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH2:10][C:11]([NH2:13])=[S:12]>C(O)C>[BrH:1].[NH2:13][C:11]1[S:12][CH:2]=[C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[N:10]=1参加物
4
実験手順
A mixture of ethyl 3-bromo-2-oxopropanoate (100 g), thiourea (39 g) and ethanol (500 ml) was refluxed for 2 hours. The reaction mixture was concentrated in vacuo. The crystalline residue was collected and washed with ethyl acetate to give ethyl 2-amino-1,3-thiazole-4-carboxylate hydrobromide (116 g).
後処理
- temperaturewas refluxed for 2 hours
- concentrationThe reaction mixture was concentrated in vacuo
- customThe crystalline residue was collected
- washwashed with ethyl acetate
出典と根拠
- ORDレコード
- ord-5e55cb4cb8894543824c526db6b5de81
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07125901B2
反応ノート
読み込み中…