Hydrochloric Acid → N-(4-{2-[4-(aminomethyl)phenyl]ethyl}-1,3-thiazol-2-yl)acetamide

HRID 1246456ノート

反応式

HRID 1246456 の反応式
C([N:3]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][C:15]2[N:16]=[C:17]([NH:20][C:21](=[O:23])[CH3:22])[S:18][CH:19]=2)=[CH:9][CH:8]=1)C=O)=O.Cl>CO.C(OCC)(=O)C>[NH2:3][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][C:15]2[N:16]=[C:17]([NH:20][C:21](=[O:23])[CH3:22])[S:18][CH:19]=2)=[CH:9][CH:8]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 21914877HCID 21914877、化合物

生成物 1

HCID 21915165N-(4-{2-[4-(aminomethyl)phenyl]ethyl}-1,3-thiazol-2-yl)acetamide収率 107.4%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of N-[4-(2-{4-[(diformylamino)methyl]phenyl}ethyl)-1,3-thiazol-2-yl]acetamide (56 mg) in methanol (0.5 ml) was added 4N hydrogen chloride in ethyl acetate (0.5 ml), and the mixture was stirred at ambient temperature for 1 hour. The reaction mixture was concentrated in vacuo. The residue was separated between chloroform (5 ml) and saturated aqueous sodium hydrogen bicarbonate (5 ml), and the aqueous layer was extracted with chloroform (5 ml). The organic layer was dried over sodium sulfate and concentrated in vacuo to give N-(4-{2-[4-(aminomethyl)phenyl]ethyl}-1,3-thiazol-2-yl)acetamide (50 mg).

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe residue was separated between chloroform (5 ml) and saturated aqueous sodium hydrogen bicarbonate (5 ml)
  3. extractionthe aqueous layer was extracted with chloroform (5 ml)
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-51fd9e9aa51d4c3da3f3db72d383624f
出典データセット
uspto-grants-2006_10
特許番号
US07125901B2

反応ノート

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