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Dimethylformamide → Methyl 3-(4-(methylthio)phenyl)propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Mercaptohydrocinnamic Acid | HCID 579784 | — |
| 生成物 | Methyl 3-(4-(methylthio)phenyl)propanoate | HCID 21914741 | — |
反応手順
3-(4-Mercaptophenyl)propanoic acid (5 g), K2CO3 (11.4 g) and DMF (30 ml) were combined, and iodomethane (5.12 ml) was added dropwise to the mixture at 0° C. under N2 atmosphere. The reaction mixture was stirred at r.t. for 13 hours, and poured into ice-water. The mixture was extracted with AcOEt. The organic layer was washed with water (twice) and brine, dried over anhydrous MgSO4, and concentrated in vacuo to give methyl 3-[4-(methylthio)phenyl]propanoate (4.19 g) as pale yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07125901B2 |
| 出典データセット | uspto-grants-2006_10 |
| ORD ID | ord-e1431242c31c4268b8a737787ecd2602 |
| 出典メモ | uspto-grants-2006_10 |