Tributylvinyltin → 2-Fluoro-4-vinylbenzonitrile

HRID 1246668ノート

反応式

HRID 1246668 の反応式
Br[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([F:10])[CH:3]=1.[CH:11]([Sn](CCCC)(CCCC)CCCC)=[CH2:12]>C1(C)C=CC=CC=1>[F:10][C:4]1[CH:3]=[C:2]([CH:11]=[CH2:12])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7]

参加物

4

反応物 2

HCID 81998TributylvinyltinHCID 7360294-Bromo-2-fluorobenzonitrile

生成物 1

HCID 219046072-Fluoro-4-vinylbenzonitrile

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 4-bromo-2-fluorobenzonitrile (4.92 g, 0.0246 mol), vinyltributyltin (0.78 g, 0.246 mol), and tetrakistriphenylphosphine (0.67 g, 0.58 mmol) in 250 mL of toluene was refluxed under nitrogen overnight. The solvent was evaporated and the residue was flash chromatographed on silica gel with heptane:CH2Cl2 (1:1) to pure CH2Cl2. A colourless oil was obtained that crystallised. Yield: 3.0 g (82%).

後処理

  1. customThe solvent was evaporated
  2. customchromatographed on silica gel with heptane:CH2Cl2 (1:1) to pure CH2Cl2
  3. customA colourless oil was obtained
  4. customthat crystallised

出典と根拠

ORDレコード
ord-cd9f1aea16614f398b75f57b875aba62
出典データセット
uspto-grants-2006_10
特許番号
US07129233B2

反応ノート

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