Sodium Methoxide → 1-(3-Chloro-2-pyridinyl)-3-hydroxy-4-piperidinecarboxylic acid
反応式
[Cl:1][C:2]1[C:3]([N:8]2[CH2:13][CH2:12][CH:11]([C:14]([O:16]CC)=[O:15])[CH:10]([OH:19])[CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.C[O-].[Na+]>O>[Cl:1][C:2]1[C:3]([N:8]2[CH2:13][CH2:12][CH:11]([C:14]([OH:16])=[O:15])[CH:10]([OH:19])[CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
Ethyl 1-(3-chloro-2-pyridinyl)-3-hydroxy-4-piperidinecarboxylate in water (55 mL) was treated with sodium methoxide (0.5 M, 8 mL, 4.0 mmol) at room temperature. After 2 hours, the mixture was concentrated under reduced pressure and the residue was purified by column chromatography to provide the title compound. MS (EI, M+H)+257.
後処理
- concentrationthe mixture was concentrated under reduced pressure
- customthe residue was purified by column chromatography
出典と根拠
- ORDレコード
- ord-ed69823d2ed14c069375cd4c6390daa9
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07129235B2
反応ノート
読み込み中…