Potassium Carbonate → 4-((4-(4-Chlorophenyl)pyrimidin-2-yl)amino)benzamide

HRID 1246761

反応式

HRID 1246761 の反応式
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)=O.[N+]([O-])(O)=O.[C:19]([NH:22][C:23]1[CH:31]=[CH:30][C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=1)(=[NH:21])[NH2:20].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[Cl:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[CH:4]=[CH:3][N:20]=[C:19]([NH:22][C:23]3[CH:31]=[CH:30][C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=3)[N:21]=2)=[CH:8][CH:9]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 5375260(E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-oneHCID 178512511HCID 178512511、化合物

生成物 1

HCID 100419644-((4-(4-Chlorophenyl)pyrimidin-2-yl)amino)benzamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of (2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one (0.10 g, 0.48 mmol), 4-(amidinoamino)benzamide nitrate (0.116 g, 0.48 mmol), and potassium carbonate (0.132 g, 0.96 mmol) in ethanol (10 ml) with was heated to 120° C. overnight in a sealed vessel. The reaction mixture was cooled to room temperature and the resulting solid was collected then washed with ethanol, water, and diethyl ether to provide the title compound as a beige solid, identical in all respects with the compound prepared in Example 1.

後処理

  1. customthe resulting solid was collected
  2. washthen washed with ethanol, water, and diethyl ether

出典と根拠

ORDレコード
ord-e5781d42b1d34adfbaa6d297610d281e
出典データセット
uspto-grants-2006_10
特許番号
US07129242B2

関連ノート

読み込み中…