化工社化工社 化学情報印刷レポート · 研究参考用
L-Hydroxyproline → 4-Hydroxy-1-(4-(4-(2-methoxy-phenylsulfanyl)-3-trifluoromethyl-phenyl)-pyridin-2-yl)-pyrrolidine-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Hydroxyproline | HCID 5810 | — |
| 反応物 | 4-Hydroxypyrrolidine | HCID 98210 | — |
| 反応物 | 2-Chloro-4-(4-(2-methoxy-phenylsulfanyl)-3-trifluoromethyl-phenyl)-pyridine | HCID 21906809 | — |
| 生成物 | 4-Hydroxy-1-(4-(4-(2-methoxy-phenylsulfanyl)-3-trifluoromethyl-phenyl)-pyridin-2-yl)-pyrrolidine-2-carboxylic acid | HCID 21906754 | — |
反応手順
The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 96 (0.039 g, 0.0985 mmol) and 3-hydroxypyrrolidine with trans-4-hydroxy-L-proline. A yellow solid 110 was obtained (0.031 g, 65%). MS (APCI) m/z 491 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07129247B2 |
| 出典データセット | uspto-grants-2006_10 |
| ORD ID | ord-627aaabb6b2941bc9795341c2c6f39b1 |
| 出典メモ | uspto-grants-2006_10 |