4-Aminophenol → 1-(4-hydroxyphenyl)-1H-pyrrole-2,5-dione
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[C:9]1(=O)[O:14][C:12](=[O:13])[CH:11]=[CH:10]1>C(O)(=O)C>[OH:8][C:5]1[CH:6]=[CH:7][C:2]([N:1]2[C:12](=[O:13])[CH:11]=[CH:10][C:9]2=[O:14])=[CH:3][CH:4]=1参加物
4
実験手順
The suspension that consists of 5.0 g (45.8 mmol) of 4-aminophenol, 4.49 g of maleic acid anhydride and 40 ml of acetic acid is refluxed for 3 hours. It is concentrated by evaporation, residual acetic acid is removed azeotropically by repeated distillation with acetic acid, and the residue is purified by chromatography on fine silica gel. 2.83 g (15.0 mmol, 33%) of the title compound is isolated.
後処理
- temperatureis refluxed for 3 hours
- concentrationIt is concentrated by evaporation, residual acetic acid
- customis removed azeotropically
- distillationdistillation with acetic acid
- customthe residue is purified by chromatography on fine silica gel
出典と根拠
- ORDレコード
- ord-ac0e729cf46a477db6c37896c9c519a3
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07129254B2
反応ノート
読み込み中…