4-Aminophenol → 1-(4-hydroxyphenyl)-1H-pyrrole-2,5-dione

HRID 1247004

反応式

HRID 1247004 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[C:9]1(=O)[O:14][C:12](=[O:13])[CH:11]=[CH:10]1>C(O)(=O)C>[OH:8][C:5]1[CH:6]=[CH:7][C:2]([N:1]2[C:12](=[O:13])[CH:11]=[CH:10][C:9]2=[O:14])=[CH:3][CH:4]=1

参加物

4

反応物 2

HCID 4034-AminophenolHCID 7923Maleic Anhydride

生成物 1

HCID 817341-(4-hydroxyphenyl)-1H-pyrrole-2,5-dione収率 33%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

The suspension that consists of 5.0 g (45.8 mmol) of 4-aminophenol, 4.49 g of maleic acid anhydride and 40 ml of acetic acid is refluxed for 3 hours. It is concentrated by evaporation, residual acetic acid is removed azeotropically by repeated distillation with acetic acid, and the residue is purified by chromatography on fine silica gel. 2.83 g (15.0 mmol, 33%) of the title compound is isolated.

後処理

  1. temperatureis refluxed for 3 hours
  2. concentrationIt is concentrated by evaporation, residual acetic acid
  3. customis removed azeotropically
  4. distillationdistillation with acetic acid
  5. customthe residue is purified by chromatography on fine silica gel

出典と根拠

ORDレコード
ord-ac0e729cf46a477db6c37896c9c519a3
出典データセット
uspto-grants-2006_10
特許番号
US07129254B2

関連ノート

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