4-(Aminomethyl)benzonitrile → (S)-N-(4-cyano-benzyl)-2-methoxy-2-phenyl-acetamide

反応式

[CH3:1][O:2][C@@H:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4]([OH:6])=O.[NH2:13][CH2:14][C:15]1[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[CH:17][CH:16]=1>>[C:14]([C:15]1[CH:22]=[CH:21][C:18]([CH2:19][NH:20][C:4](=[O:6])[C@@H:3]([O:2][CH3:1])[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:17][CH:16]=1)#[N:13]

参加物

反応物 2

HCID 826084-(Aminomethyl)benzonitrile

HCID 643325(+)-Methoxyphenylacetic acid

生成物 1

HCID 69290213(S)-N-(4-cyano-benzyl)-2-methoxy-2-phenyl-acetamide

実験手順

(S)-(+)-Methoxyphenylacetic acid was coupled with 4-aminomethyl benzonitrile (CAS No: 10406-25-4) according to general procedure C to give (S)-N-(4-cyano-benzyl)-2-methoxy-2-phenyl-acetamide as an off-white solid. MS 281.2 ([M+H]+)

出典と根拠

ORDレコード: ord-5c5a5257c5344b73a5ee7f84c0f0ef61
出典データセット: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07129238B2

反応ノート

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