4-Aminomethyl-3-hydroxy-benzonitrile hydrochloride → (RS)-N-(4-cyano-2-hydroxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide

HRID 1247354

反応式

HRID 1247354 の反応式
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([F:10])[C:3]=1[CH:11]([O:15][CH2:16][CH3:17])[C:12]([OH:14])=O.Cl.[NH2:19][CH2:20][C:21]1[CH:28]=[CH:27][C:24]([C:25]#[N:26])=[CH:23][C:22]=1[OH:29]>>[C:25]([C:24]1[CH:27]=[CH:28][C:21]([CH2:20][NH:19][C:12](=[O:14])[CH:11]([C:3]2[C:4]([F:10])=[CH:5][C:6]([O:8][CH3:9])=[CH:7][C:2]=2[F:1])[O:15][CH2:16][CH3:17])=[C:22]([OH:29])[CH:23]=1)#[N:26]

参加物

3

反応物 2

HCID 219056834-Aminomethyl-3-hydroxy-benzonitrile hydrochlorideHCID 21905754(RS)-(2,6-Difluoro-4-methoxy-phenyl)-ethoxy-acetic acid

生成物 1

HCID 21905119(RS)-N-(4-cyano-2-hydroxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide

実験手順

(RS)-(2,6-Difluoro-4-methoxy-phenyl)-ethoxy-acetic acid (example 101.3) was coupled with 4-aminomethyl-3-hydroxy-benzonitrile hydrochloride (example 110.2) according to general procedure B to give (RS)-N-(4-cyano-2-hydroxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide. Colorless foam. MS 375.4 ([M−H]−)

出典と根拠

ORDレコード
ord-48b55bf0af7b44fba7384ab585c7ec25
出典データセット
uspto-grants-2006_10
特許番号
US07129238B2

関連ノート

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