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Sulfuric Acid → 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 1H-Pyrazole-1-ethanol, 5-amino-4-nitroso- | HCID 10149014 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate | HCID 11673148 | — |
反応手順
A solution of 5-amino-1-(2-hydroxyethyl)-4-nitrosopyrazole (97 g) in a mixed solvent of sulfuric acid (34 ml) and water (2000 ml) was treated with 10% palladium on carbon (10 g) under a hydrogen atmosphere at room temperature for 4 days. After the catalyst was filtered off, the filtrate was concentrated in vacuo. The residue was triturated with methanol and dried in vacuo to give 4,5-diamino-1-(2-hydroxyethyl)pyrazole sulfuric acid salt (90.2 g) as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07129232B2 |
| 出典データセット | uspto-grants-2006_10 |
| ORD ID | ord-bf3e239bfe704c928fd15c7ee1f8a9f2 |
| 出典メモ | uspto-grants-2006_10 |