Hydrochloric Acid → 1H-Pyrazol-5-amine,1-(2-fluoroethyl)-(9CI)

HRID 1247843ノート

反応式

HRID 1247843 の反応式
[F:1][CH2:2][CH2:3][N:4]1[C:8]([NH:9]C=O)=[CH:7][CH:6]=[N:5]1.Cl>CO>[F:1][CH2:2][CH2:3][N:4]1[C:8]([NH2:9])=[CH:7][CH:6]=[N:5]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 85666041HCID 85666041、化合物

生成物 1

HCID 219045531H-Pyrazol-5-amine,1-(2-fluoroethyl)-(9CI)収率 93%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of [1-(2-fluoroethyl)-1H-pyrazol-5-yl]formamide (15.7 g) in methanol (78 ml) was added concentrated hydrochloric acid (21 ml) at room temperature. The reaction mixture was stirred for 3.5 hours and evaporated in vacuo. The residue was dissolved in ethyl acetate and washed with aqueous sodium hydrogen carbonate solution. The organic layer was dried over magnesium sulfate and concentrated in vacuo to give 1-(2-fluoroethyl)-1H-pyrazol-5-amine (12 g).

後処理

  1. customevaporated in vacuo
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. washwashed with aqueous sodium hydrogen carbonate solution
  4. dry with materialThe organic layer was dried over magnesium sulfate
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-e8f5b1f3ed5345d3b0d33a8807d2cb7d
出典データセット
uspto-grants-2006_10
特許番号
US07129232B2

反応ノート

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