Methyl Isocyanate → HCID 20279741、化合物

HRID 1247869ノート

反応式

HRID 1247869 の反応式
Cl.[CH2:2]([NH:14][NH2:15])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[OH-].[K+].[CH3:18][N:19]=[C:20]=[O:21]>C(OCC)C>[CH3:18][NH:19][C:20]([N:14]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[NH2:15])=[O:21]

参加物

5

反応物 3

HCID 12228Methyl IsocyanateHCID 14797Potassium HydroxideHCID 20279742HCID 20279742、化合物

生成物 1

HCID 20279741HCID 20279741、化合物収率 94.7%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A stirred, degassed suspension of dodecylhydrazine hydrochloride (4.62 g, 0.017 mole) in diethyl ether (15 mL) was cooled under nitrogen and 4N aqueous potassium hydroxide (8.7 mL, 0.035 mole) was added. Stirring was continued as methyl isocyanate (0.97 g, 0.017 mole) in 5 mL diethyl ether was added dropwise. The mixture was filtered to yield 4.12 g (94.7%) N-methyl-1-dodecyl-hydrazinecarboxamide (m.p. 73°-75° C.). NMR analysis confirmed the structure.

後処理

  1. customA stirred, degassed
  2. temperaturewas cooled under nitrogen
  3. additionwas added dropwise
  4. filtrationThe mixture was filtered

出典と根拠

ORDレコード
ord-65043bcda5634aca90dd0bcf9f2fa99c
出典データセット
uspto-grants-1985_06
特許番号
US04521325

反応ノート

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