Ethylenediamine → 6-[3-bromo-4-(1,3-diazacyclopenten-2-ylamino)-phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone

HRID 1247887

反応式

HRID 1247887 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][C:3]=1[Br:16].CS[N:19]=[C:20]=O.[CH2:22](N)[CH2:23][NH2:24]>>[Br:16][C:3]1[CH:4]=[C:5]([C:8]2[CH:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)[CH:6]=[CH:7][C:2]=1[NH:1][C:20]1[NH:19][CH2:22][CH2:23][N:24]=1

参加物

4

反応物 3

HCID 3301EthylenediamineHCID 202792156-(4-Amino-3-bromophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-oneHCID 21933440Methylthioisocyanate

生成物 1

HCID 132173476-[3-bromo-4-(1,3-diazacyclopenten-2-ylamino)-phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone

実験手順

Using 6-(4-amino-3-bromophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone and methylthioisocyanate, the reaction was carried out in the same manner as described in Example 1(b) to the corresponding methylisothiuronium salt which was then reacted with ethylenediamine in the same manner as described in Example 1(c) to afford the above-identified compound. M.P. 265°-267° C. (with decomp.).

後処理

  1. customto afford the above-identified compound

出典と根拠

ORDレコード
ord-7edb9ac9cca4413199e59b4400518b73
出典データセット
uspto-grants-1985_06
特許番号
US04521415

関連ノート

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