3-Chloro-3-phenyl-2-propenal → Phenyl(7-phenylpyrazolo[1,5-a]pyrimidin-3-yl)methanone
反応式
Cl[C:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[CH:3][CH:4]=O.[NH2:12][C:13]1[C:17]([C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:19])=[CH:16][NH:15][N:14]=1>C(O)(=O)C>[C:20]1([C:18]([C:17]2[CH:16]=[N:15][N:14]3[C:2]([C:6]4[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=4)=[CH:3][CH:4]=[N:12][C:13]=23)=[O:19])[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1参加物
4
実験手順
A mixture of 0.01 mole of 3-chloro-3-phenyl-2-propenal and 0.01 mole of (3-amino-1H-pyrazol-4-yl)phenyl-methanone in 25 ml of acetic acid was refluxed for 6 hours. The solvent was removed in vacuo and the product isolated as described in Example 1, giving the desired product as crystals, mp 163°-165° C.
後処理
- temperaturewas refluxed for 6 hours