Ethanol → 2-Furanyl(7-phenylpyrazolo[1,5-a]pyrimidin-3-yl)methanone

HRID 1247964ノート

反応式

HRID 1247964 の反応式
[NH2:1][C:2]1[C:6]([C:7]([C:9]2[O:10][CH:11]=[CH:12][CH:13]=2)=[O:8])=[CH:5][NH:4][N:3]=1.[CH2:14](O)[CH3:15]>B(F)(F)F.CCOCC>[O:10]1[CH:11]=[CH:12][CH:13]=[C:9]1[C:7]([C:6]1[CH:5]=[N:4][N:3]2[C:13]([C:15]3[CH:14]=[CH:9][CH:7]=[CH:6][CH:5]=3)=[CH:12][CH:11]=[N:1][C:2]=12)=[O:8]

参加物

4

反応物 2

HCID 702EthanolHCID 178509268HCID 178509268、化合物

生成物 1

HCID 134759012-Furanyl(7-phenylpyrazolo[1,5-a]pyrimidin-3-yl)methanone

試薬・触媒・溶媒 1

HCID 8000Boron trifluoride etherate触媒

実験手順

A mixture of 0.86 g of (3-amino-1H-pyrazol-4-yl)-2-furanylmethanone and 0.63 g of 1-phenyl-1-propynone in 35 ml of ethanol with several drops of boron trifluoride etherate was refluxed for 18 hours. The solvent was removed and the residue chromatographed on silica gel with ethyl acetate:hexane (1:20) as eluent and a gradual change to ethyl acetate:hexane (2:5). Elution with ethyl acetate gave a solid which was recrystallized from dichloromethanehexane, giving the desired product, mp 185°-187° C.

後処理

  1. temperaturewas refluxed for 18 hours
  2. customThe solvent was removed
  3. customthe residue chromatographed on silica gel with ethyl acetate:hexane (1:20) as eluent
  4. washElution with ethyl acetate
  5. customgave a solid which
  6. customwas recrystallized from dichloromethanehexane

出典と根拠

ORDレコード
ord-14df1ce0d4b049c5bfa939f3ec9fb66c
出典データセット
uspto-grants-1985_06
特許番号
US04521422

反応ノート

読み込み中…