4-[3-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine → 1-(3-Pyridylacetyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]([O:10]C2C=CC([N+]([O-])=O)=CC=2)=O)[CH:2]=1.[F:20][C:21]([F:35])([F:34])[C:22]1[CH:23]=[C:24]([C:28]2[CH2:29][CH2:30][NH:31][CH2:32][CH:33]=2)[CH:25]=[CH:26][CH:27]=1>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]([N:31]2[CH2:30][CH:29]=[C:28]([C:24]3[CH:25]=[CH:26][CH:27]=[C:22]([C:21]([F:20])([F:34])[F:35])[CH:23]=3)[CH2:33][CH2:32]2)=[O:10])[CH:2]=1参加物
4
実験手順
A suspension of 11.3 g of p-nitrophenyl 3-pyridylacetate and 10 g of 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine in 150 ml of ethanol is stirred 1 hour at room temperature, then concentrated under reduced pressure. The residue is dissolved in diethyl ether, the solution is washed with water, then with sodium hydroxide and again with water, dried on anhydrous sodium sulfate and concentrated. Thus, 1-(3-pyridylacetyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine (8 g) is obtained as an oil which is used for the subsequent reaction.