N-benzyl-N-(5,6-dimethoxy-1-indanyl)glycine hydrochloride → N-(5,6-dimethoxy-1-indanyl)glycine

HRID 1248049ノート

反応式

HRID 1248049 の反応式
Cl.C([N:9]([CH:14]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[CH2:16][CH2:15]1)[CH2:10][C:11]([OH:13])=[O:12])C1C=CC=CC=1>C(O)C.[C].[Pd]>[CH3:26][O:25][C:19]1[CH:18]=[C:17]2[C:22](=[CH:21][C:20]=1[O:23][CH3:24])[CH:14]([NH:9][CH2:10][C:11]([OH:13])=[O:12])[CH2:15][CH2:16]2

参加物

4

反応物 1

HCID 20280785N-benzyl-N-(5,6-dimethoxy-1-indanyl)glycine hydrochloride

生成物 1

HCID 13472326N-(5,6-dimethoxy-1-indanyl)glycine収率 85.9%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

N-Benzyl-N-(5,6-dimethoxy-1-indanyl)glycine hydrochloride (14 g) is dissolved in 300 ml of ethanol, 3.0 g of 5% palladium-carbon is added and catalytic reduction is carried out at ordinary temperature and pressure. After absorption of the calculated amount of hydrogen, the catalyst is filtered off, and the ethanol is distilled off under reduced pressure. The residue is dissolved in 10 ml of water and adjusted to pH 7.0 with aqueous ammonia. The crystalline precipitates are collected by filtration, washed with a small amount of water, and dried, to give 8.0 g of N-(5,6-dimethoxy-1-indanyl)glycine as colorless needles. Melting point: 213°-216° C.

後処理

  1. customAfter absorption of the calculated amount of hydrogen
  2. filtrationthe catalyst is filtered off
  3. distillationthe ethanol is distilled off under reduced pressure
  4. dissolutionThe residue is dissolved in 10 ml of water
  5. customThe crystalline precipitates
  6. filtrationare collected by filtration
  7. washwashed with a small amount of water
  8. customdried

出典と根拠

ORDレコード
ord-7e1aaa7c2056474abb958520d9448f26
出典データセット
uspto-grants-1985_06
特許番号
US04521607

反応ノート

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