Dimethyl Sulfoxide → HCID 13264093、化合物
反応式
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[CH2:13]Cl.[CH:15]([O-:17])=[O:16].[Na+].CS(C)=O>O>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[CH2:13][O:17][CH:15]=[O:16]参加物
5
実験手順
24.5 parts by weight of 3,7-dichloro-8-chloromethylquinoline and 13 parts by weight of sodium formate in 220 parts by weight of dimethylsulfoxide are heated for 6 hours at 100° C. The mixture is then cooled, water is added and the precipitated product is filtered off under suction and recrystallized from toluene. 21.5 parts by weight (84% of theory) of 3,7-dichloro-8-formyloxymethylquinoline of melting point 146° C. are obtained.
後処理
- temperatureThe mixture is then cooled
- filtrationthe precipitated product is filtered off under suction
- customrecrystallized from toluene
出典と根拠
- ORDレコード
- ord-50cef2755fd84adebd5d91ee9f02e72d
- 出典データセット
- uspto-grants-1985_06
- 特許番号
- US04522646
反応ノート
読み込み中…